project

Diamond Grant VII

Diamond Grant VII – Ministry of Science and Higher Education DI2017 005247

Project title: Synthesis and testing of application properties of new high-performance photoinitiating systems dedicated to new generation dental photocuring composites 

Project period: 19.09.2018 – 18.09.2022

Grant amount: 220 000 PLN

The main goal of this project is the synthesis of high-performance photoinitiating systems dedicated to photo-curable polymer dental composites for dental fillings. Due to the long search for very effective photoinitiating systems for a new generation of dental composite materials based on epoxy resins, oxiranes, oxetanes and siloranes, the project proposed a research plan regarding application issues for this type of materials. In addition, the scope of research work has been extended to include cognitive aspects related to the development of completely new initiating systems (single-component or multi-component) showing the versatility of action through the possibility of photochemical initiation:

  • cationic photopolymerization with ring opening for new generation dental materials, e.g. FiltekTM Siloran  by 3M; 
  • free-radical photopolymerization as standard used in photocurable dental materials;
  • hybrid photopolymerization involving cationic ring-opening photopolymerization and radical chain photopolymerization.

For this purpose, first, the synthesis of completely new systems was planned for the role of initiating systems based on onium salt systems, including iodonium and sulfonium salts with a co-initiator or photosensitizer in the form of chromophores with absorption characteristics adapted to the currently used Vis-LED dental light sources (from 400 nm to 550 nm). The photoinitiators obtained in this way with appropriate absorption characteristics are also tested in terms of their effectiveness and initiation efficiency of cationic and radical photopolymerization of monomers used as a matrix in dental composites.

As part of the project, new initiation systems dedicated to the preparation of next-generation dental composites have already been developed, which have a number of significant advantages compared to the standard camphorquinone / aromatic amine initiator system.

Published in peer-reviewed journals from the JCR list:

1. High-performance photoinitiating systems for new generation dental fillings

Journal: Dental Materials (IF 6.3, Ministerial Points:140).

Authors: Monika Topa-Skwarczyńska, Magdalena Jankowska, Alicja Gruchała-Hałat, Filip Petko, Mariusz Galek, Joanna Ortyl

2. Novel formulations containing fluorescent sensors to improve the resolution of 3D prints

Journal: International Journal of Molecular Sciences (IF 6.208, Ministerial Points:140).

Authors: Monika Topa-Skwarczyńska, Andrzej Świeży, Dominika Krok, Katarzyna Starzak, Paweł Niezgoda, Bartosz Oksiuta, Weronika Wałczyk, Joanna Ortyl

3. Novel Effective Photoinitiators for the Production of Dental Fillings

Journal: Journal of Photopolymer Science and Technology(IF 0,518, Ministerial Points: 40).

Authors: Monika Topa, Joanna Ortyl

4. Development of the first panchromatic BODIPY-based one-component iodonium salts for initiating the photopolymerization processes

Journal: Polymer Chemistry (IF 5.582, Ministerial Points: 140).

Authors: Monika Topa-Skwarczyńska, Mariusz Galek, Magdalena Jankowska, Fabrice Morlet-Savary, Bernadette Graff, Jacques Lalevée, Roman Popielarz, Joanna Ortyl


In December 2021, this article was selected by the editors of the prestigious Polymer Chemistry magazine as the best article of the month -> link to the website!

5. Moving Towards a Finer Way of Light-Cured Resin-Based Restorative Dental Materials: Recent Advances in Photoinitiating Systems Based on Iodonium Salts

Journal: Materials (IF 3.057, Ministerial Points: 140).

Authors: Monika Topa, Joanna Ortyl



Patents and patent applications:

  1. Patent application WIPO ST 10/C PL441957, application number P.441957
    Date of application: 07.08.2022
    Title in Polish: Nowe sole jodoniowe, sposób wytwarzania nowych soli jodoniowych, zastosowania nowych soli jodoniowych, nowe kompozyty fotoutwardzalne przeznaczone na wypełnienia stomatologiczne, sposób wytwarzania nowych kompozytów fotoutwardzalnych przeznaczonych na wypełnienia stomatologiczne, nowe dwuskładnikowe systemy fotoinicjujące, nowe pochodne bifenylu i zastosowanie pochodnych bifenylu
    Translation of the title in English: New iodonium salts, method for producing new iodonium salts, applications of new iodonium salts, new photocurable composites intended for dental fillings, method for producing new photocurable composites intended for dental fillings, new two-component photoinitiating systems, new biphenyl derivatives and the use of biphenyl derivatives
    Authors: Monika Topa-Skwarczyńska, Joanna Ortyl, Marcin Galek, Filip Petko
    Owner of the patent: Politechnika Krakowska (Cracow University of Technology)

  2. Patent application WIPO ST 10/C PL441956, application number P.441956
    Date of application: 07.08.2022
    Title in Polish: Nowe sole jodoniowe, sposób wytwarzania nowych soli jodoniowych, zastosowania nowych soli jodoniowych, nowe kompozyty fotoutwardzalne przeznaczone na wypełnienia stomatologiczne, sposób wytwarzania nowych kompozytów fotoutwardzalnych przeznaczonych na wypełnienia stomatologiczne, nowe dwuskładnikowe systemy fotoinicjujące, nowe pochodne benzenu i zastosowanie pochodnych benzenu
    Translation of the title in English: New iodonium salts, method for producing new iodonium salts, applications of new iodonium salts, new photocurable composites intended for dental fillings, method for producing new photocurable composites intended for dental fillings, new two-component photoinitiating systems, new benzene derivatives and the use of benzene derivatives
    Authors: Monika Topa-Skwarczyńska, Joanna Ortyl, Marcin Galek
    Owner of the patent: Politechnika Krakowska (Cracow University of Technology)

  3. Granted national patent WIPO ST 10/C PL238234, former application number P.431489
    Date of patent grant: 13.05.2021
    Date of application: 16.10.2019
    Title in Polish: Nowe sole jodoniowe, sposób ich wytwarzania i zastosowania
    Translation of the title in English: New iodonium salts, their method of preparation and applications
    Authors: Monika Topa, Joanna Ortyl, Marcin Galek
    Owner of the patent: Politechnika Krakowska (Cracow University of Technology)


Post-conference/monographs:

  1. M. Topa-Skwarczyńska, Production of polymer coatings by photopolymerization using novel, effective photoinitiators and simultaneously colorimetric sensors to control the quality of the process, ETCC 2022 European Technical Coatings Congress, [in:] book of abstracts

  2. M. Topa-Skwarczyńska, J. Ortyl, The first panchromatic one-component BODIPY based iodonium salts exhibiting absorption in the 400–600 nm spectral range for cationic photopolymerization for 3D printing, 7th European Symposium of Photopolymer Science (ESPS 2022), [in:] book of abstracts, page 34

  3. M. Topa, Moving towards Non-toxic, Completely Safe Light-cured Dental Materials: Novel Effective Photoinitiators for the Production of Dental Fillings, The 38th International Conference of Photopolymer Science and Technology, [in:] book of abstracts, online, 2021

  4. M. Topa, The use of ultraviolet-LEDs and visible-LEDs for obtaining new generation dental composites, 2021 IUVA World Congress, [in:] book of abstracts, online, 2021

  5. M. Topa, M. Galek, J. Ortyl, Novel safe amine-free initiating systems for the preparation of photo-cured dental materials, 7th Young Polymer Scientists Conference and Short Course (7YPSCSC 2021), [in:] program and abstracts, page 167

  6. M. Topa, J. Ortyl, Nanosilica as the Inorganic Filler for Dental Composites Obtained by Photopolymerization, NANOSTRUCTURED BIOCERAMIC MATERIALS 2020 (NBCM 2020), [in:] conference book, Vilnius University Press, ISBN 978-609-07-0557-5

  7. M. Topa, J. Ortyl, Zwiększenie efektywności procesu fotopolimeryzacji dla standardowych monomerów stosowanych w produkcji kompozytów stomatologicznych, Materiały Polimerowe Pomerania-Plast 2019, [in:] conference monograph, edited by E. Wiśniewska, B. Schmidt, K. Kowalczyk, Wydawnictwo Uczelniane ZUT w Szczecinie, ISBN 978-83-7663-276-6, page 76

  8. M. Topa, Novel efficient photoinitiating systems for dental light-cure composite resins, Modern Polymeric Materials for Environmental Applications, Vol. 7, 2019, edited by K. Pielichowski, ISBN 978-83-937270-6-3, pages 465–474

  9. M. Topa, J. Ortyl, Photopolymerization kinetics of a dimethacrylate compositions in thick sample for dental applications determined by real-time FT-IR method, Nano and Fast Vibrational Spectroscopy 2019, [in:] book of abstracts, page 45



Conferences:

  1. 7th European Symposium of Photopolymer Science (ESPS2022)
    Date and place of the conference: 19–22.09.2022, Istanbul, Turkey
    Scope of the conference: international conference
    Title of presentation: The first panchromatic one-component BODIPY-based iodonium salts exhibiting absorption in the 400–600 nm spectral range for cationic photopolymerization for 3D printing
    Authors: Monika Topa-Skwarczyńska (project leader)

  2. ETCC2022 European Technical Coatings Congress
    Date and place of the conference: 12–14.07.2022, Kraków, Poland
    Scope of the conference: international conference
    Title of presentation: Production of polymer coatings by photopolymerisation using novel, effective photoinitiators and simultaneously colorimetric sensors to control the quality of the process
    Authors: Monika Topa-Skwarczyńska (project leader)

  3. 7th Young Polymer Scientists Conference and Short Course (7YPSCSC 2021)
    Date and place of the conference: 27–28.09.2021, Łódź, Poland, online
    Scope of the conference: international conference
    Title of presentation: Novel safe amine-free initiating systems for the preparation of photo-cured dental materials
    Authors: Monika Topa-Skwarczyńska (project leader)

  4. The 38th International Conference of Photopolymer Science and Technology
    Date and place of the conference: 15–16.06.2021, online
    Scope of the conference: international conference
    Title of presentation: Moving towards non-toxic, completely safe light-cured dental materials: novel effective photoinitiators for the production of dental filling
    Authors: Monika Topa-Skwarczyńska (project leader)

  5. 2021 IUVA World Congress
    Date and place of the conference: 07–08.06.2021, online
    Scope of the conference: international conference
    Title of presentation: The use of ultraviolet-LEDs and visible-LEDs for obtaining new generation dental composites
    Authors: Monika Topa-Skwarczyńska (project leader)

  6. Nanostructured Bioceramic Materials 2020
    Date and place of the conference: 01–03.12.2020, Vilnius, Lithuania
    Scope of the conference: international conference
    Title of presentation: Nanosilica as the inorganic filler for dental composites obtained by photopolymerization
    Authors: Monika Topa-Skwarczyńska (project leader)

  7. 7th International Seminar on Modern Polymeric Materials for Environmental Applications
    Date and place of the conference: 15–17.05.2019, Kraków, Poland
    Scope of the conference: international conference
    Title of presentation: Novel efficient photoinitiating systems for dental light-cure composite resins
    Authors: Monika Topa-Skwarczyńska (project leader)

  8. VII Scientific Conference, Polymeric Materials Pomerania-Plast 2019
    Date and place of the conference: 05–07.06.2019, Międzyzdroje, Poland
    Scope of the conference: national conference (specialist)
    Title of presentation (in Polish): Zwiększenie efektywności procesu fotopolimeryzacji dla standardowych monomerów stosowanych w produkcji kompozytów stomatologicznych
    Authors: Monika Topa-Skwarczyńska (project leader)

  9. Seminar Nano and Fast Vibrational Spectroscopy
    Date and place of the conference: 17–18.06.2019, Kraków, Poland
    Scope of the conference: international conference
    Title of presentation: Photopolymerization kinetics of dimethacrylate compositions in thick samples for dental applications determined by the real-time FT-IR method
    Authors: Monika Topa-Skwarczyńska (project leader)



Medals at international exhibitions:


  1. International Warsaw Invention Show IWIS 2022
    Solution title: First Panchromatic BODIPY-Based One-Component Iodonium Salts Exhibiting Absorption in the 400–600 nm Spectral Range for Cationic Photopolymerization for Dental and 3D Printing Industries | Type of award: team (Monika Topa-Skwarczyńska, Magdalena Jankowska, Małgorzata Noworyta, Joanna Ortyl) | Date and venue: 18.10.2022, Warsaw | Award: Gold medal

  2. XIII International Invention and Innovation Show INTARG® 2020 – Social Innovations (Special Edition)
    Solution title: Novel Effective Initiating Systems Absorbing in the Visible Light Range for Obtaining New Generation, Completely Safe Dental Composites | Type of award: team (Monika Topa, Joanna Ortyl, Mariusz Galek) | Date and venue: 10.11.2020, Katowice | Award: Diamond award, Gold medal, Special Award from the honorary patron TISIAS (Toronto International Society of Innovation & Advanced Skills), and Special Award from the Polonia International Foundation

  3. Korea International Women’s Invention Exposition 2020 (KIWIE 2020)
    Solution title: Moving Towards Non-Toxic, Completely Safe Light-Cured Dental Materials: Novel Effective Photoinitiators for the Production of Dental Fillings | Type of award: team (Monika Topa, Joanna Ortyl, Mariusz Galek) | Date and venue: 23.10–25.10.2020, Republic of Korea | Award: Silver medal and Special Award from the Korea Institute of Patent Information



Other achievements:

  1. April 2022 – Participation in KRAKDENT® International Dental Fair (Kraków)
    The project leader attended the 28th International Dental Fair KRAKDENT® (07–09.04.2022) to promote newly developed dental composites created under the Diamond Grant project and to learn about the needs of dental professionals.

  2. November 2021 – Participation in DENTAMED® Dental Fair (Wrocław)
    The project leader took part in the 19th Lower Silesian Dental Fair DENTAMED® (05–06.11.2021), presenting innovative dental composites developed within the Diamond Grant project and engaging with practitioners to better understand clinical expectations.

  3. European Biotech Week – Innovation Is in Our Genes 2021
    The project leader took part in the European Biotech Week series dedicated to biotechnology and innovation (27.09–03.10.2021), presenting innovative non-toxic dental composites developed within the Diamond Grant project in an oral presentation titled “Safe, New Generation Non-Toxic Dental Composites”

  4. 2020 – Finalist of the “25 under 25” Competition (Forbes & McKinsey & Company)
    The project leader was a finalist in the “25 under 25” competition in the Science category, presenting research on new dental composite materials. The achievement was featured in Forbes magazine and on the websites of McKinsey & Company.

  5. 2019/2020 – Laureate of the Shesnnovation Academy Program
    The project leader was awarded in the Shesnnovation Academy 2019/20 program, aimed at developing entrepreneurial and business skills to establish a start-up focused on novel dental composites.

  6. 2019 – Presentation at Life Science Open Space Forum (Kraków)
    The project leader presented research results from the Diamond Grant project at Life Science Open Space 2019 (29.11.2019), an Open Forum for Cooperation and Innovation in Health and Quality of Life, establishing connections with companies such as 3M. A note on the research outcomes was published on the event website.



Online Dissemination of the Project
A description of the Diamond Grant project titled “Synthesis and testing of application properties of new high-performance photoinitiating systems dedicated to new generation dental photocuring composites ” was published on:
The website of the Faculty of Chemical Engineering and Technology, Cracow University of Technology.
The website of the research team led by Dr. Joanna Ortyl, the project supervisor.